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n methylmorpholine nmm  (Loba Chemie)
86
Loba Chemie n methylmorpholine nmm
(A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and <t>Oxyma,</t> <t>N-methylmorpholine</t> <t>(NMM),</t> in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.
N Methylmorpholine Nmm, supplied by Loba Chemie, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/n methylmorpholine nmm/product/Loba Chemie
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n methylmorpholine nmm - by Bioz Stars, 2026-06
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n methylmorpholine  (Tokyo Chemical Industry)
86
Tokyo Chemical Industry n methylmorpholine
(A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and <t>Oxyma,</t> <t>N-methylmorpholine</t> <t>(NMM),</t> in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.
N Methylmorpholine, supplied by Tokyo Chemical Industry, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/n methylmorpholine/product/Tokyo Chemical Industry
Average 86 stars, based on 1 article reviews
n methylmorpholine - by Bioz Stars, 2026-06
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n-methylmorpholine (nmm)  (Nacalai)
90
Nacalai n-methylmorpholine (nmm)
(A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and <t>Oxyma,</t> <t>N-methylmorpholine</t> <t>(NMM),</t> in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.
N Methylmorpholine (Nmm), supplied by Nacalai, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/n-methylmorpholine (nmm)/product/Nacalai
Average 90 stars, based on 1 article reviews
n-methylmorpholine (nmm) - by Bioz Stars, 2026-06
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n-methylmorpholine  (Merck KGaA)
90
Merck KGaA n-methylmorpholine
(A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and <t>Oxyma,</t> <t>N-methylmorpholine</t> <t>(NMM),</t> in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.
N Methylmorpholine, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/n-methylmorpholine/product/Merck KGaA
Average 90 stars, based on 1 article reviews
n-methylmorpholine - by Bioz Stars, 2026-06
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n-methylmorpholine n-oxide monohydrate nmmo–h2o  (Oakwood Chemical)
90
Oakwood Chemical n-methylmorpholine n-oxide monohydrate nmmo–h2o
(A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and <t>Oxyma,</t> <t>N-methylmorpholine</t> <t>(NMM),</t> in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.
N Methylmorpholine N Oxide Monohydrate Nmmo–H2o, supplied by Oakwood Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/n-methylmorpholine n-oxide monohydrate nmmo–h2o/product/Oakwood Chemical
Average 90 stars, based on 1 article reviews
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n-methylmorpholine nmm  (Thermo Fisher)
90
Thermo Fisher n-methylmorpholine nmm
(A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and <t>Oxyma,</t> <t>N-methylmorpholine</t> <t>(NMM),</t> in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.
N Methylmorpholine Nmm, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/n-methylmorpholine nmm/product/Thermo Fisher
Average 90 stars, based on 1 article reviews
n-methylmorpholine nmm - by Bioz Stars, 2026-06
90/100 stars
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n -methylmorpholine (nmm)  (Thermo Fisher)
90
Thermo Fisher n -methylmorpholine (nmm)
(A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and <t>Oxyma,</t> <t>N-methylmorpholine</t> <t>(NMM),</t> in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.
N Methylmorpholine (Nmm), supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/n -methylmorpholine (nmm)/product/Thermo Fisher
Average 90 stars, based on 1 article reviews
n -methylmorpholine (nmm) - by Bioz Stars, 2026-06
90/100 stars
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n-methylmorpholine (nmm)  (Aladdin Technology Co Ltd)
90
Aladdin Technology Co Ltd n-methylmorpholine (nmm)
(A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and <t>Oxyma,</t> <t>N-methylmorpholine</t> <t>(NMM),</t> in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.
N Methylmorpholine (Nmm), supplied by Aladdin Technology Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/n-methylmorpholine (nmm)/product/Aladdin Technology Co Ltd
Average 90 stars, based on 1 article reviews
n-methylmorpholine (nmm) - by Bioz Stars, 2026-06
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Image Search Results


(A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and Oxyma, N-methylmorpholine (NMM), in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.

Journal: bioRxiv

Article Title: Thermal-Acoustic Activation of Hydrophobic Polystyrene Supports for High-Efficiency Aqueous Solid-Phase Peptide Synthesis

doi: 10.64898/2026.05.05.722603

Figure Lengend Snippet: (A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and Oxyma, N-methylmorpholine (NMM), in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.

Article Snippet: N, N’ -diisopropylethylamine (DIPEA) (CAS Number: 387649), N-methylmorpholine (NMM) (CAS Number: 109-02-4), piperedine (PIP) (CAS Number: 110-89-4), (Acetic anhydride (CAS Number: 108-24-7) acetonitrile (ACN) (CAS Number: 75-05-8), methanol (MeOH) (CAS Number: 67-56-1), isopropyl alcohol (IPA) (CAS Number: 67-63-0), N, N’ -dimethylformamide (DMF) (CAS Number: 68-12-2), dichloromethane (DCM) (CAS Number: 75-09-2), trifluoroacetic acid (TFA) (CAS Number: 76-05-1), triisopropylsilane (TIS) (CAS Number: T1533), diethyl ether (CAS Number: 60-29-7), and tert-butyl methyl ether (CAS Number: 1634-04-4) were obtained from Loba Chemie Private Limited.

Techniques: Activation Assay, Dissolution, Dispersion, Irradiation

Schematic representation of the coupling mechanism of Fmoc-protected amino acids on 2-chlorotrityl chloride (2-CTC) polystyrene resin under thermal–acoustic conditions. Initially, N -Methylmorpholine (NMM) is dissolved in water ( Step-1 ), and the Fmoc-amino acid is further dissolved in this mixture under heating and ultrasonic irradiation, generating a homogeneous aqueous solution ( Step-2 ). Upon addition of EDC·HCl, the carboxylate group is activated to form an O -acylisourea intermediate ( Step-3 ), which is subsequently stabilized by Oxyma to produce a reactive active ester ( Step-4 ). Under thermal–acoustic conditions, the activated ester diffuses into the hydrophobic resin matrix and reacts with the free amine ( Step-5 ), resulting in amide bond formation and extension of the peptide chain ( Step-6 ).

Journal: bioRxiv

Article Title: Thermal-Acoustic Activation of Hydrophobic Polystyrene Supports for High-Efficiency Aqueous Solid-Phase Peptide Synthesis

doi: 10.64898/2026.05.05.722603

Figure Lengend Snippet: Schematic representation of the coupling mechanism of Fmoc-protected amino acids on 2-chlorotrityl chloride (2-CTC) polystyrene resin under thermal–acoustic conditions. Initially, N -Methylmorpholine (NMM) is dissolved in water ( Step-1 ), and the Fmoc-amino acid is further dissolved in this mixture under heating and ultrasonic irradiation, generating a homogeneous aqueous solution ( Step-2 ). Upon addition of EDC·HCl, the carboxylate group is activated to form an O -acylisourea intermediate ( Step-3 ), which is subsequently stabilized by Oxyma to produce a reactive active ester ( Step-4 ). Under thermal–acoustic conditions, the activated ester diffuses into the hydrophobic resin matrix and reacts with the free amine ( Step-5 ), resulting in amide bond formation and extension of the peptide chain ( Step-6 ).

Article Snippet: N, N’ -diisopropylethylamine (DIPEA) (CAS Number: 387649), N-methylmorpholine (NMM) (CAS Number: 109-02-4), piperedine (PIP) (CAS Number: 110-89-4), (Acetic anhydride (CAS Number: 108-24-7) acetonitrile (ACN) (CAS Number: 75-05-8), methanol (MeOH) (CAS Number: 67-56-1), isopropyl alcohol (IPA) (CAS Number: 67-63-0), N, N’ -dimethylformamide (DMF) (CAS Number: 68-12-2), dichloromethane (DCM) (CAS Number: 75-09-2), trifluoroacetic acid (TFA) (CAS Number: 76-05-1), triisopropylsilane (TIS) (CAS Number: T1533), diethyl ether (CAS Number: 60-29-7), and tert-butyl methyl ether (CAS Number: 1634-04-4) were obtained from Loba Chemie Private Limited.

Techniques: Irradiation